• Housing Move-In
    August 18 8:00am
    Students will be moving their items into campus housing for the 2017-2018 academic year.  There will be student volunteers to assist. more »
  • CLOSED
    August 19 12:00am
    Closed more »
  • Lecture-Seminar Hari Nakshatri
    August 19 9:00am
    Hari Nakshatri, PhD, Director of Education is giving a seminar to med students and researchers regarding breast cancer research. more »
  • IU School of Public Health Alumni Board Meeting
    August 19 4:30pm
    For additional information, please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
  • 2017 IUPUI and IU Symphony on the Prairie
    August 19 6:00pm
    Summer in Indianapolis isn't complete without an alumni trip to Symphony on the Prairie. Join other IUPUI and IU alumni from across Central Indiana on August 19 for the music of Fleetwood Mac. The Central Indiana Chapter of the IU Alumni Association will again host a wine tasting with proceeds benefiting the Diabetes Youth Foundation of Indi more »
Friday, August 18, 2017
    IU Calendar




    • Housing Move-In
      August 18 8:00am
      Students will be moving their items into campus housing for the 2017-2018 academic year.  There will be student volunteers to assist. more »
    • CLOSED
      August 19 12:00am
      Closed more »
    • Lecture-Seminar Hari Nakshatri
      August 19 9:00am
      Hari Nakshatri, PhD, Director of Education is giving a seminar to med students and researchers regarding breast cancer research. more »
    • IU School of Public Health Alumni Board Meeting
      August 19 4:30pm
      For additional information, please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
    • 2017 IUPUI and IU Symphony on the Prairie
      August 19 6:00pm
      Summer in Indianapolis isn't complete without an alumni trip to Symphony on the Prairie. Join other IUPUI and IU alumni from across Central Indiana on August 19 for the music of Fleetwood Mac. The Central Indiana Chapter of the IU Alumni Association will again host a wine tasting with proceeds benefiting the Diabetes Youth Foundation of Indi more »
    Friday, August 18, 2017
      IU Calendar




      • Housing Move-In
        August 18 8:00am
        Students will be moving their items into campus housing for the 2017-2018 academic year.  There will be student volunteers to assist. more »
      • CLOSED
        August 19 12:00am
        Closed more »
      • Lecture-Seminar Hari Nakshatri
        August 19 9:00am
        Hari Nakshatri, PhD, Director of Education is giving a seminar to med students and researchers regarding breast cancer research. more »
      • IU School of Public Health Alumni Board Meeting
        August 19 4:30pm
        For additional information, please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
      • 2017 IUPUI and IU Symphony on the Prairie
        August 19 6:00pm
        Summer in Indianapolis isn't complete without an alumni trip to Symphony on the Prairie. Join other IUPUI and IU alumni from across Central Indiana on August 19 for the music of Fleetwood Mac. The Central Indiana Chapter of the IU Alumni Association will again host a wine tasting with proceeds benefiting the Diabetes Youth Foundation of Indi more »
      Friday, August 18, 2017
        IU Calendar




        • Housing Move-In
          August 18 8:00am
          Students will be moving their items into campus housing for the 2017-2018 academic year.  There will be student volunteers to assist. more »
        • CLOSED
          August 19 12:00am
          Closed more »
        • Lecture-Seminar Hari Nakshatri
          August 19 9:00am
          Hari Nakshatri, PhD, Director of Education is giving a seminar to med students and researchers regarding breast cancer research. more »
        • IU School of Public Health Alumni Board Meeting
          August 19 4:30pm
          For additional information, please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
        • 2017 IUPUI and IU Symphony on the Prairie
          August 19 6:00pm
          Summer in Indianapolis isn't complete without an alumni trip to Symphony on the Prairie. Join other IUPUI and IU alumni from across Central Indiana on August 19 for the music of Fleetwood Mac. The Central Indiana Chapter of the IU Alumni Association will again host a wine tasting with proceeds benefiting the Diabetes Youth Foundation of Indi more »
        Friday, August 18, 2017

          About This Event

          Summary

          Generating Practice-based Evidence from Electronic Health Records

          Abstract: In the era of EHRs, it is possible to examine the outcomes of decisions made by doctors during clinical practice to identify patterns of care that are optimal—generating evidence based on the collective practice of experts. We will discuss informatics methods that transform unstructured patient notes into a de-identified, temporally ordered, patient-feature matrix.  With the resulting high-throughput data, it is possible to monitor for adverse drug events, profile specific drugs, identify off-label drug usage, uncover ‘natural experiments’ and generate practice-based evidence for difficult-to-test clinical hypotheses. We will review four use-cases to illustrate the usefulness of learning practice-based evidence from unstructured clinical notes. 

          By examining the frequency and co-frequency of drug and disease mentions, we can detect associations among drugs and their adverse events about 2 years before an alert is issued as well as learn the prevalence of known drug-drug interactions. Using the patient feature matrix as well as prior knowledge about drugs, diseases, and known usage, we identify novel off-label uses; ranked on the basis of drug safety and cost. We uncover a natural experiment—a subset of CHF patients who were prescribed Cilostazol despite its black box warning—and profile its safety in this high-risk group of patients. We will discuss a use case of testing a clinical hypothesis about a possible association between allergic conditions and the complication of chronic uveitis in juvenile idiopathic arthritis (JIA) patients.

          Bio: Dr. Nigam Shah is assistant professor of Medicine (Biomedical Informatics) at Stanford University, where he Assistant Director of the Center for Biomedical Informatics Research, a member of the Biomedical Informatics Graduate Program and a core member of the National Center for Biomedical Ontology. His group develops methods to annotate, index and analyze large unstructured datasets for enabling use cases of the learning health system. His research has demonstrated that by using unstructured clinical data it is possible to monitor for adverse drug events, learn drug-drug interactions, identify off-label drug usage, find practice-based evidence for difficult-to-test clinical hypotheses, and generate phenotypic fingerprints of diseases.

          Dr. Shah received the AMIA New Investigator Award for 2013. Dr. Shah integrates teaching into his advanced research work and was recognized with the Biosciences Faculty Teaching Award for outstanding teaching contributions in his graduate class on “Data driven medicine” (Biomedin 215). He holds an MBBS from Baroda Medical College, India, a PhD from Penn State University and completed postdoctoral training at Stanford University. More at: https://cap.stanford.edu/profiles/stanford/Nigam_Shah

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          Contact Information

          Elizabeth Bunge
          ebunge@iupui.edu

          Event Site --- None ---
          Registration --- None ---

          Event Schedule

          There are no upcoming dates for this event.

          IU Calendar




          • Housing Move-In
            August 18 8:00am
            Students will be moving their items into campus housing for the 2017-2018 academic year.  There will be student volunteers to assist. more »
          • CLOSED
            August 19 12:00am
            Closed more »
          • Lecture-Seminar Hari Nakshatri
            August 19 9:00am
            Hari Nakshatri, PhD, Director of Education is giving a seminar to med students and researchers regarding breast cancer research. more »
          • IU School of Public Health Alumni Board Meeting
            August 19 4:30pm
            For additional information, please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
          • 2017 IUPUI and IU Symphony on the Prairie
            August 19 6:00pm
            Summer in Indianapolis isn't complete without an alumni trip to Symphony on the Prairie. Join other IUPUI and IU alumni from across Central Indiana on August 19 for the music of Fleetwood Mac. The Central Indiana Chapter of the IU Alumni Association will again host a wine tasting with proceeds benefiting the Diabetes Youth Foundation of Indi more »
          Friday, August 18, 2017