• Competition Pool
    May 24 5:30am
    Lap swim more »
  • IU Pediatric Dental Alumni Suite
    May 25 12:00am
    For more information please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
  • Excel 2016: The Basics
    May 25 9:00am
    This session is being delivered online and simultaneously in room 144 in Wells Library in Bloomington. This is the online session, so please register for this session only if you plan to attend remotely. This workshop lasts 3 hours, a more »
  • IU Simon Cancer Center Summer Research Program Welcome Dinner
    May 25 4:00pm
    The IU Simon Cancer Center Summer Research Program aims to increase the number of undergraduate students from underrepresented populations pursuing biomedical and behavioral science careers by providing positive and meaningful firsthand exposure to these fields.   Tonight is the welcome dinner more »
  • Organizations and Religion; Religion, Spirituality, Healthcare, and Ethics Seminar
    May 25 6:00pm
    Facilitators:  Steven S. Ivy, PhD & David Craig, PhD Dinner and books will be provided free of charge. RSVP to srush7@iuhealth.org by May 11 so we can mail books and plan the meal. PLEASE PROVIDE A MAILING ADDRESS, CAMPUS OR US MAIL.   Readings:  Craig, D.M. (2014). Health care as a social good : religious more »
Wednesday, May 24, 2017
    IU Calendar




    • Competition Pool
      May 24 5:30am
      Lap swim more »
    • IU Pediatric Dental Alumni Suite
      May 25 12:00am
      For more information please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
    • Excel 2016: The Basics
      May 25 9:00am
      This session is being delivered online and simultaneously in room 144 in Wells Library in Bloomington. This is the online session, so please register for this session only if you plan to attend remotely. This workshop lasts 3 hours, a more »
    • IU Simon Cancer Center Summer Research Program Welcome Dinner
      May 25 4:00pm
      The IU Simon Cancer Center Summer Research Program aims to increase the number of undergraduate students from underrepresented populations pursuing biomedical and behavioral science careers by providing positive and meaningful firsthand exposure to these fields.   Tonight is the welcome dinner more »
    • Organizations and Religion; Religion, Spirituality, Healthcare, and Ethics Seminar
      May 25 6:00pm
      Facilitators:  Steven S. Ivy, PhD & David Craig, PhD Dinner and books will be provided free of charge. RSVP to srush7@iuhealth.org by May 11 so we can mail books and plan the meal. PLEASE PROVIDE A MAILING ADDRESS, CAMPUS OR US MAIL.   Readings:  Craig, D.M. (2014). Health care as a social good : religious more »
    Wednesday, May 24, 2017
      IU Calendar




      • Competition Pool
        May 24 5:30am
        Lap swim more »
      • IU Pediatric Dental Alumni Suite
        May 25 12:00am
        For more information please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
      • Excel 2016: The Basics
        May 25 9:00am
        This session is being delivered online and simultaneously in room 144 in Wells Library in Bloomington. This is the online session, so please register for this session only if you plan to attend remotely. This workshop lasts 3 hours, a more »
      • IU Simon Cancer Center Summer Research Program Welcome Dinner
        May 25 4:00pm
        The IU Simon Cancer Center Summer Research Program aims to increase the number of undergraduate students from underrepresented populations pursuing biomedical and behavioral science careers by providing positive and meaningful firsthand exposure to these fields.   Tonight is the welcome dinner more »
      • Organizations and Religion; Religion, Spirituality, Healthcare, and Ethics Seminar
        May 25 6:00pm
        Facilitators:  Steven S. Ivy, PhD & David Craig, PhD Dinner and books will be provided free of charge. RSVP to srush7@iuhealth.org by May 11 so we can mail books and plan the meal. PLEASE PROVIDE A MAILING ADDRESS, CAMPUS OR US MAIL.   Readings:  Craig, D.M. (2014). Health care as a social good : religious more »
      Wednesday, May 24, 2017
        IU Calendar




        • Competition Pool
          May 24 5:30am
          Lap swim more »
        • IU Pediatric Dental Alumni Suite
          May 25 12:00am
          For more information please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
        • Excel 2016: The Basics
          May 25 9:00am
          This session is being delivered online and simultaneously in room 144 in Wells Library in Bloomington. This is the online session, so please register for this session only if you plan to attend remotely. This workshop lasts 3 hours, a more »
        • IU Simon Cancer Center Summer Research Program Welcome Dinner
          May 25 4:00pm
          The IU Simon Cancer Center Summer Research Program aims to increase the number of undergraduate students from underrepresented populations pursuing biomedical and behavioral science careers by providing positive and meaningful firsthand exposure to these fields.   Tonight is the welcome dinner more »
        • Organizations and Religion; Religion, Spirituality, Healthcare, and Ethics Seminar
          May 25 6:00pm
          Facilitators:  Steven S. Ivy, PhD & David Craig, PhD Dinner and books will be provided free of charge. RSVP to srush7@iuhealth.org by May 11 so we can mail books and plan the meal. PLEASE PROVIDE A MAILING ADDRESS, CAMPUS OR US MAIL.   Readings:  Craig, D.M. (2014). Health care as a social good : religious more »
        Wednesday, May 24, 2017

          About This Event

          Summary

          Generating Practice-based Evidence from Electronic Health Records

          Abstract: In the era of EHRs, it is possible to examine the outcomes of decisions made by doctors during clinical practice to identify patterns of care that are optimal—generating evidence based on the collective practice of experts. We will discuss informatics methods that transform unstructured patient notes into a de-identified, temporally ordered, patient-feature matrix.  With the resulting high-throughput data, it is possible to monitor for adverse drug events, profile specific drugs, identify off-label drug usage, uncover ‘natural experiments’ and generate practice-based evidence for difficult-to-test clinical hypotheses. We will review four use-cases to illustrate the usefulness of learning practice-based evidence from unstructured clinical notes. 

          By examining the frequency and co-frequency of drug and disease mentions, we can detect associations among drugs and their adverse events about 2 years before an alert is issued as well as learn the prevalence of known drug-drug interactions. Using the patient feature matrix as well as prior knowledge about drugs, diseases, and known usage, we identify novel off-label uses; ranked on the basis of drug safety and cost. We uncover a natural experiment—a subset of CHF patients who were prescribed Cilostazol despite its black box warning—and profile its safety in this high-risk group of patients. We will discuss a use case of testing a clinical hypothesis about a possible association between allergic conditions and the complication of chronic uveitis in juvenile idiopathic arthritis (JIA) patients.

          Bio: Dr. Nigam Shah is assistant professor of Medicine (Biomedical Informatics) at Stanford University, where he Assistant Director of the Center for Biomedical Informatics Research, a member of the Biomedical Informatics Graduate Program and a core member of the National Center for Biomedical Ontology. His group develops methods to annotate, index and analyze large unstructured datasets for enabling use cases of the learning health system. His research has demonstrated that by using unstructured clinical data it is possible to monitor for adverse drug events, learn drug-drug interactions, identify off-label drug usage, find practice-based evidence for difficult-to-test clinical hypotheses, and generate phenotypic fingerprints of diseases.

          Dr. Shah received the AMIA New Investigator Award for 2013. Dr. Shah integrates teaching into his advanced research work and was recognized with the Biosciences Faculty Teaching Award for outstanding teaching contributions in his graduate class on “Data driven medicine” (Biomedin 215). He holds an MBBS from Baroda Medical College, India, a PhD from Penn State University and completed postdoctoral training at Stanford University. More at: https://cap.stanford.edu/profiles/stanford/Nigam_Shah

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          Contact Information

          Elizabeth Bunge
          ebunge@iupui.edu

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          Event Schedule

          There are no upcoming dates for this event.

          IU Calendar




          • Competition Pool
            May 24 5:30am
            Lap swim more »
          • IU Pediatric Dental Alumni Suite
            May 25 12:00am
            For more information please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
          • Excel 2016: The Basics
            May 25 9:00am
            This session is being delivered online and simultaneously in room 144 in Wells Library in Bloomington. This is the online session, so please register for this session only if you plan to attend remotely. This workshop lasts 3 hours, a more »
          • IU Simon Cancer Center Summer Research Program Welcome Dinner
            May 25 4:00pm
            The IU Simon Cancer Center Summer Research Program aims to increase the number of undergraduate students from underrepresented populations pursuing biomedical and behavioral science careers by providing positive and meaningful firsthand exposure to these fields.   Tonight is the welcome dinner more »
          • Organizations and Religion; Religion, Spirituality, Healthcare, and Ethics Seminar
            May 25 6:00pm
            Facilitators:  Steven S. Ivy, PhD & David Craig, PhD Dinner and books will be provided free of charge. RSVP to srush7@iuhealth.org by May 11 so we can mail books and plan the meal. PLEASE PROVIDE A MAILING ADDRESS, CAMPUS OR US MAIL.   Readings:  Craig, D.M. (2014). Health care as a social good : religious more »
          Wednesday, May 24, 2017