• Competition Pool
    January 18 5:30am
    Lap Swim more »
  • Craig McDaniel + Jean Robertson | Close Reading
    January 18 10:00am
    In Close Reading, Herron faculty members Jean Robertson and Craig McDaniel explore the relationship of visual and verbal modes of communicating and expressing meaning. more »
  • Tom Sachs | Radiant City: Paintings 2000-2016
    January 18 10:00am
    A major survey exhibition of Tom Sachs’ paintings showcasing the artist’s ongoing interest in combining mass-produced pop cultural icons with a hand made aesthetic. This exhibition is made possible in part by the generous support of Julie and David Eskenazi. more »
  • Hans Op de Beeck | Staging Silence (2)
    January 18 10:00am
    In Belgian artist Hans Op de Beeck's film, the real and the imaginary fuse as anonymous hands assemble miniature dioramas of timeless, dreamlike settings. more »
  • Sophomore "Chew on This" Series
    January 18 12:00pm
    Calling all sophomores! This semester will be busy, so come by for tips and tricks to make this semester the best one. Free food and a change to win awesome JagSwag! more »
Wednesday, January 18, 2017
    IU Calendar




    • Competition Pool
      January 18 5:30am
      Lap Swim more »
    • Craig McDaniel + Jean Robertson | Close Reading
      January 18 10:00am
      In Close Reading, Herron faculty members Jean Robertson and Craig McDaniel explore the relationship of visual and verbal modes of communicating and expressing meaning. more »
    • Tom Sachs | Radiant City: Paintings 2000-2016
      January 18 10:00am
      A major survey exhibition of Tom Sachs’ paintings showcasing the artist’s ongoing interest in combining mass-produced pop cultural icons with a hand made aesthetic. This exhibition is made possible in part by the generous support of Julie and David Eskenazi. more »
    • Hans Op de Beeck | Staging Silence (2)
      January 18 10:00am
      In Belgian artist Hans Op de Beeck's film, the real and the imaginary fuse as anonymous hands assemble miniature dioramas of timeless, dreamlike settings. more »
    • Sophomore "Chew on This" Series
      January 18 12:00pm
      Calling all sophomores! This semester will be busy, so come by for tips and tricks to make this semester the best one. Free food and a change to win awesome JagSwag! more »
    Wednesday, January 18, 2017
      IU Calendar




      • Competition Pool
        January 18 5:30am
        Lap Swim more »
      • Craig McDaniel + Jean Robertson | Close Reading
        January 18 10:00am
        In Close Reading, Herron faculty members Jean Robertson and Craig McDaniel explore the relationship of visual and verbal modes of communicating and expressing meaning. more »
      • Tom Sachs | Radiant City: Paintings 2000-2016
        January 18 10:00am
        A major survey exhibition of Tom Sachs’ paintings showcasing the artist’s ongoing interest in combining mass-produced pop cultural icons with a hand made aesthetic. This exhibition is made possible in part by the generous support of Julie and David Eskenazi. more »
      • Hans Op de Beeck | Staging Silence (2)
        January 18 10:00am
        In Belgian artist Hans Op de Beeck's film, the real and the imaginary fuse as anonymous hands assemble miniature dioramas of timeless, dreamlike settings. more »
      • Sophomore "Chew on This" Series
        January 18 12:00pm
        Calling all sophomores! This semester will be busy, so come by for tips and tricks to make this semester the best one. Free food and a change to win awesome JagSwag! more »
      Wednesday, January 18, 2017
        IU Calendar




        • Competition Pool
          January 18 5:30am
          Lap Swim more »
        • Craig McDaniel + Jean Robertson | Close Reading
          January 18 10:00am
          In Close Reading, Herron faculty members Jean Robertson and Craig McDaniel explore the relationship of visual and verbal modes of communicating and expressing meaning. more »
        • Tom Sachs | Radiant City: Paintings 2000-2016
          January 18 10:00am
          A major survey exhibition of Tom Sachs’ paintings showcasing the artist’s ongoing interest in combining mass-produced pop cultural icons with a hand made aesthetic. This exhibition is made possible in part by the generous support of Julie and David Eskenazi. more »
        • Hans Op de Beeck | Staging Silence (2)
          January 18 10:00am
          In Belgian artist Hans Op de Beeck's film, the real and the imaginary fuse as anonymous hands assemble miniature dioramas of timeless, dreamlike settings. more »
        • Sophomore "Chew on This" Series
          January 18 12:00pm
          Calling all sophomores! This semester will be busy, so come by for tips and tricks to make this semester the best one. Free food and a change to win awesome JagSwag! more »
        Wednesday, January 18, 2017

          About This Event

          Summary

          Generating Practice-based Evidence from Electronic Health Records

          Abstract: In the era of EHRs, it is possible to examine the outcomes of decisions made by doctors during clinical practice to identify patterns of care that are optimal—generating evidence based on the collective practice of experts. We will discuss informatics methods that transform unstructured patient notes into a de-identified, temporally ordered, patient-feature matrix.  With the resulting high-throughput data, it is possible to monitor for adverse drug events, profile specific drugs, identify off-label drug usage, uncover ‘natural experiments’ and generate practice-based evidence for difficult-to-test clinical hypotheses. We will review four use-cases to illustrate the usefulness of learning practice-based evidence from unstructured clinical notes. 

          By examining the frequency and co-frequency of drug and disease mentions, we can detect associations among drugs and their adverse events about 2 years before an alert is issued as well as learn the prevalence of known drug-drug interactions. Using the patient feature matrix as well as prior knowledge about drugs, diseases, and known usage, we identify novel off-label uses; ranked on the basis of drug safety and cost. We uncover a natural experiment—a subset of CHF patients who were prescribed Cilostazol despite its black box warning—and profile its safety in this high-risk group of patients. We will discuss a use case of testing a clinical hypothesis about a possible association between allergic conditions and the complication of chronic uveitis in juvenile idiopathic arthritis (JIA) patients.

          Bio: Dr. Nigam Shah is assistant professor of Medicine (Biomedical Informatics) at Stanford University, where he Assistant Director of the Center for Biomedical Informatics Research, a member of the Biomedical Informatics Graduate Program and a core member of the National Center for Biomedical Ontology. His group develops methods to annotate, index and analyze large unstructured datasets for enabling use cases of the learning health system. His research has demonstrated that by using unstructured clinical data it is possible to monitor for adverse drug events, learn drug-drug interactions, identify off-label drug usage, find practice-based evidence for difficult-to-test clinical hypotheses, and generate phenotypic fingerprints of diseases.

          Dr. Shah received the AMIA New Investigator Award for 2013. Dr. Shah integrates teaching into his advanced research work and was recognized with the Biosciences Faculty Teaching Award for outstanding teaching contributions in his graduate class on “Data driven medicine” (Biomedin 215). He holds an MBBS from Baroda Medical College, India, a PhD from Penn State University and completed postdoctoral training at Stanford University. More at: https://cap.stanford.edu/profiles/stanford/Nigam_Shah

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          Contact Information

          Elizabeth Bunge
          ebunge@iupui.edu

          Event Site --- None ---
          Registration --- None ---

          Event Schedule

          There are no upcoming dates for this event.

          IU Calendar




          • Competition Pool
            January 18 5:30am
            Lap Swim more »
          • Craig McDaniel + Jean Robertson | Close Reading
            January 18 10:00am
            In Close Reading, Herron faculty members Jean Robertson and Craig McDaniel explore the relationship of visual and verbal modes of communicating and expressing meaning. more »
          • Tom Sachs | Radiant City: Paintings 2000-2016
            January 18 10:00am
            A major survey exhibition of Tom Sachs’ paintings showcasing the artist’s ongoing interest in combining mass-produced pop cultural icons with a hand made aesthetic. This exhibition is made possible in part by the generous support of Julie and David Eskenazi. more »
          • Hans Op de Beeck | Staging Silence (2)
            January 18 10:00am
            In Belgian artist Hans Op de Beeck's film, the real and the imaginary fuse as anonymous hands assemble miniature dioramas of timeless, dreamlike settings. more »
          • Sophomore "Chew on This" Series
            January 18 12:00pm
            Calling all sophomores! This semester will be busy, so come by for tips and tricks to make this semester the best one. Free food and a change to win awesome JagSwag! more »
          Wednesday, January 18, 2017