• CLOSED
    December 16 12:00am
    Closed more »
  • Holiday Classic
    December 16 7:00am
    Columbus North Athletics sponsored swim meet. more »
  • IU HCOP Saturday Senior Academy
    December 16 10:00am
    The Saturday Senior Academy participants will receive information about health careers that will halp them make future career choices.  They will participate in on-site and off-site visits.  IU HCOP mentors will be present at all times.  more »
  • CLOSED
    December 17 12:00am
    The competition lap pool for lap swim is closed. more »
  • Holiday Training
    December 18 12:00am
    Holiday Training more »
Saturday, December 16, 2017
    IU Calendar




    • CLOSED
      December 16 12:00am
      Closed more »
    • Holiday Classic
      December 16 7:00am
      Columbus North Athletics sponsored swim meet. more »
    • IU HCOP Saturday Senior Academy
      December 16 10:00am
      The Saturday Senior Academy participants will receive information about health careers that will halp them make future career choices.  They will participate in on-site and off-site visits.  IU HCOP mentors will be present at all times.  more »
    • CLOSED
      December 17 12:00am
      The competition lap pool for lap swim is closed. more »
    • Holiday Training
      December 18 12:00am
      Holiday Training more »
    Saturday, December 16, 2017
      IU Calendar




      • CLOSED
        December 16 12:00am
        Closed more »
      • Holiday Classic
        December 16 7:00am
        Columbus North Athletics sponsored swim meet. more »
      • IU HCOP Saturday Senior Academy
        December 16 10:00am
        The Saturday Senior Academy participants will receive information about health careers that will halp them make future career choices.  They will participate in on-site and off-site visits.  IU HCOP mentors will be present at all times.  more »
      • CLOSED
        December 17 12:00am
        The competition lap pool for lap swim is closed. more »
      • Holiday Training
        December 18 12:00am
        Holiday Training more »
      Saturday, December 16, 2017
        IU Calendar




        • CLOSED
          December 16 12:00am
          Closed more »
        • Holiday Classic
          December 16 7:00am
          Columbus North Athletics sponsored swim meet. more »
        • IU HCOP Saturday Senior Academy
          December 16 10:00am
          The Saturday Senior Academy participants will receive information about health careers that will halp them make future career choices.  They will participate in on-site and off-site visits.  IU HCOP mentors will be present at all times.  more »
        • CLOSED
          December 17 12:00am
          The competition lap pool for lap swim is closed. more »
        • Holiday Training
          December 18 12:00am
          Holiday Training more »
        Saturday, December 16, 2017

          About This Event

          Summary

          Generating Practice-based Evidence from Electronic Health Records

          Abstract: In the era of EHRs, it is possible to examine the outcomes of decisions made by doctors during clinical practice to identify patterns of care that are optimal—generating evidence based on the collective practice of experts. We will discuss informatics methods that transform unstructured patient notes into a de-identified, temporally ordered, patient-feature matrix.  With the resulting high-throughput data, it is possible to monitor for adverse drug events, profile specific drugs, identify off-label drug usage, uncover ‘natural experiments’ and generate practice-based evidence for difficult-to-test clinical hypotheses. We will review four use-cases to illustrate the usefulness of learning practice-based evidence from unstructured clinical notes. 

          By examining the frequency and co-frequency of drug and disease mentions, we can detect associations among drugs and their adverse events about 2 years before an alert is issued as well as learn the prevalence of known drug-drug interactions. Using the patient feature matrix as well as prior knowledge about drugs, diseases, and known usage, we identify novel off-label uses; ranked on the basis of drug safety and cost. We uncover a natural experiment—a subset of CHF patients who were prescribed Cilostazol despite its black box warning—and profile its safety in this high-risk group of patients. We will discuss a use case of testing a clinical hypothesis about a possible association between allergic conditions and the complication of chronic uveitis in juvenile idiopathic arthritis (JIA) patients.

          Bio: Dr. Nigam Shah is assistant professor of Medicine (Biomedical Informatics) at Stanford University, where he Assistant Director of the Center for Biomedical Informatics Research, a member of the Biomedical Informatics Graduate Program and a core member of the National Center for Biomedical Ontology. His group develops methods to annotate, index and analyze large unstructured datasets for enabling use cases of the learning health system. His research has demonstrated that by using unstructured clinical data it is possible to monitor for adverse drug events, learn drug-drug interactions, identify off-label drug usage, find practice-based evidence for difficult-to-test clinical hypotheses, and generate phenotypic fingerprints of diseases.

          Dr. Shah received the AMIA New Investigator Award for 2013. Dr. Shah integrates teaching into his advanced research work and was recognized with the Biosciences Faculty Teaching Award for outstanding teaching contributions in his graduate class on “Data driven medicine” (Biomedin 215). He holds an MBBS from Baroda Medical College, India, a PhD from Penn State University and completed postdoctoral training at Stanford University. More at: https://cap.stanford.edu/profiles/stanford/Nigam_Shah

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          Contact Information

          Elizabeth Bunge
          ebunge@iupui.edu

          Event Site --- None ---
          Registration --- None ---

          Event Schedule

          There are no upcoming dates for this event.

          IU Calendar




          • CLOSED
            December 16 12:00am
            Closed more »
          • Holiday Classic
            December 16 7:00am
            Columbus North Athletics sponsored swim meet. more »
          • IU HCOP Saturday Senior Academy
            December 16 10:00am
            The Saturday Senior Academy participants will receive information about health careers that will halp them make future career choices.  They will participate in on-site and off-site visits.  IU HCOP mentors will be present at all times.  more »
          • CLOSED
            December 17 12:00am
            The competition lap pool for lap swim is closed. more »
          • Holiday Training
            December 18 12:00am
            Holiday Training more »
          Saturday, December 16, 2017