• Competition Pool
    April 24 5:30am
    Lap Swim more »
  • Kindness Week: Conversation Hour: How Has, and Can, the UWC Support Connection
    April 24 1:00pm
    Join us for a conversation in CA 427 exploring how the Writing Center has, and can, support connection. Kindness Week is brought to you by the IUPUI University Writing Center. more »
  • Kindness Week: "Englishes, Racism, & Me: A Love Story" reading by Sydney Fleck
    April 24 5:00pm
    Join us in CA 427 for a reading of "Englishes, Racism, & Me: A Love Story," a narrative piece by UWC consultant and writing virtuoso Sydney Fleck! Kindness Week is brought to you by the IUPUI University Writing Center. more »
  • The Struggle to Create America's Holocaust Museum
    April 24 6:00pm
    Lecture by Dr. Edward T. Linenthal Professor of History, Indiana University IUPUI’s Department of Religious Studies invites you to join one of the country’s foremost academic authorities on memorials and sacred spaces for a lecture on the development, building, and impact of the U.S. Holocaust Memorial Museum. April more »
  • IUPUI Department of Music and Arts Technology - Acoustic Guitar Ensemble
    April 24 7:30pm
    Acoustic Guitar Ensemble more »
Monday, April 24, 2017
    IU Calendar




    • Competition Pool
      April 24 5:30am
      Lap Swim more »
    • Kindness Week: Conversation Hour: How Has, and Can, the UWC Support Connection
      April 24 1:00pm
      Join us for a conversation in CA 427 exploring how the Writing Center has, and can, support connection. Kindness Week is brought to you by the IUPUI University Writing Center. more »
    • Kindness Week: "Englishes, Racism, & Me: A Love Story" reading by Sydney Fleck
      April 24 5:00pm
      Join us in CA 427 for a reading of "Englishes, Racism, & Me: A Love Story," a narrative piece by UWC consultant and writing virtuoso Sydney Fleck! Kindness Week is brought to you by the IUPUI University Writing Center. more »
    • The Struggle to Create America's Holocaust Museum
      April 24 6:00pm
      Lecture by Dr. Edward T. Linenthal Professor of History, Indiana University IUPUI’s Department of Religious Studies invites you to join one of the country’s foremost academic authorities on memorials and sacred spaces for a lecture on the development, building, and impact of the U.S. Holocaust Memorial Museum. April more »
    • IUPUI Department of Music and Arts Technology - Acoustic Guitar Ensemble
      April 24 7:30pm
      Acoustic Guitar Ensemble more »
    Monday, April 24, 2017
      IU Calendar




      • Competition Pool
        April 24 5:30am
        Lap Swim more »
      • Kindness Week: Conversation Hour: How Has, and Can, the UWC Support Connection
        April 24 1:00pm
        Join us for a conversation in CA 427 exploring how the Writing Center has, and can, support connection. Kindness Week is brought to you by the IUPUI University Writing Center. more »
      • Kindness Week: "Englishes, Racism, & Me: A Love Story" reading by Sydney Fleck
        April 24 5:00pm
        Join us in CA 427 for a reading of "Englishes, Racism, & Me: A Love Story," a narrative piece by UWC consultant and writing virtuoso Sydney Fleck! Kindness Week is brought to you by the IUPUI University Writing Center. more »
      • The Struggle to Create America's Holocaust Museum
        April 24 6:00pm
        Lecture by Dr. Edward T. Linenthal Professor of History, Indiana University IUPUI’s Department of Religious Studies invites you to join one of the country’s foremost academic authorities on memorials and sacred spaces for a lecture on the development, building, and impact of the U.S. Holocaust Memorial Museum. April more »
      • IUPUI Department of Music and Arts Technology - Acoustic Guitar Ensemble
        April 24 7:30pm
        Acoustic Guitar Ensemble more »
      Monday, April 24, 2017
        IU Calendar




        • Competition Pool
          April 24 5:30am
          Lap Swim more »
        • Kindness Week: Conversation Hour: How Has, and Can, the UWC Support Connection
          April 24 1:00pm
          Join us for a conversation in CA 427 exploring how the Writing Center has, and can, support connection. Kindness Week is brought to you by the IUPUI University Writing Center. more »
        • Kindness Week: "Englishes, Racism, & Me: A Love Story" reading by Sydney Fleck
          April 24 5:00pm
          Join us in CA 427 for a reading of "Englishes, Racism, & Me: A Love Story," a narrative piece by UWC consultant and writing virtuoso Sydney Fleck! Kindness Week is brought to you by the IUPUI University Writing Center. more »
        • The Struggle to Create America's Holocaust Museum
          April 24 6:00pm
          Lecture by Dr. Edward T. Linenthal Professor of History, Indiana University IUPUI’s Department of Religious Studies invites you to join one of the country’s foremost academic authorities on memorials and sacred spaces for a lecture on the development, building, and impact of the U.S. Holocaust Memorial Museum. April more »
        • IUPUI Department of Music and Arts Technology - Acoustic Guitar Ensemble
          April 24 7:30pm
          Acoustic Guitar Ensemble more »
        Monday, April 24, 2017

          About This Event

          Summary

          Generating Practice-based Evidence from Electronic Health Records

          Abstract: In the era of EHRs, it is possible to examine the outcomes of decisions made by doctors during clinical practice to identify patterns of care that are optimal—generating evidence based on the collective practice of experts. We will discuss informatics methods that transform unstructured patient notes into a de-identified, temporally ordered, patient-feature matrix.  With the resulting high-throughput data, it is possible to monitor for adverse drug events, profile specific drugs, identify off-label drug usage, uncover ‘natural experiments’ and generate practice-based evidence for difficult-to-test clinical hypotheses. We will review four use-cases to illustrate the usefulness of learning practice-based evidence from unstructured clinical notes. 

          By examining the frequency and co-frequency of drug and disease mentions, we can detect associations among drugs and their adverse events about 2 years before an alert is issued as well as learn the prevalence of known drug-drug interactions. Using the patient feature matrix as well as prior knowledge about drugs, diseases, and known usage, we identify novel off-label uses; ranked on the basis of drug safety and cost. We uncover a natural experiment—a subset of CHF patients who were prescribed Cilostazol despite its black box warning—and profile its safety in this high-risk group of patients. We will discuss a use case of testing a clinical hypothesis about a possible association between allergic conditions and the complication of chronic uveitis in juvenile idiopathic arthritis (JIA) patients.

          Bio: Dr. Nigam Shah is assistant professor of Medicine (Biomedical Informatics) at Stanford University, where he Assistant Director of the Center for Biomedical Informatics Research, a member of the Biomedical Informatics Graduate Program and a core member of the National Center for Biomedical Ontology. His group develops methods to annotate, index and analyze large unstructured datasets for enabling use cases of the learning health system. His research has demonstrated that by using unstructured clinical data it is possible to monitor for adverse drug events, learn drug-drug interactions, identify off-label drug usage, find practice-based evidence for difficult-to-test clinical hypotheses, and generate phenotypic fingerprints of diseases.

          Dr. Shah received the AMIA New Investigator Award for 2013. Dr. Shah integrates teaching into his advanced research work and was recognized with the Biosciences Faculty Teaching Award for outstanding teaching contributions in his graduate class on “Data driven medicine” (Biomedin 215). He holds an MBBS from Baroda Medical College, India, a PhD from Penn State University and completed postdoctoral training at Stanford University. More at: https://cap.stanford.edu/profiles/stanford/Nigam_Shah

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          Contact Information

          Elizabeth Bunge
          ebunge@iupui.edu

          Event Site --- None ---
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          Event Schedule

          There are no upcoming dates for this event.

          IU Calendar




          • Competition Pool
            April 24 5:30am
            Lap Swim more »
          • Kindness Week: Conversation Hour: How Has, and Can, the UWC Support Connection
            April 24 1:00pm
            Join us for a conversation in CA 427 exploring how the Writing Center has, and can, support connection. Kindness Week is brought to you by the IUPUI University Writing Center. more »
          • Kindness Week: "Englishes, Racism, & Me: A Love Story" reading by Sydney Fleck
            April 24 5:00pm
            Join us in CA 427 for a reading of "Englishes, Racism, & Me: A Love Story," a narrative piece by UWC consultant and writing virtuoso Sydney Fleck! Kindness Week is brought to you by the IUPUI University Writing Center. more »
          • The Struggle to Create America's Holocaust Museum
            April 24 6:00pm
            Lecture by Dr. Edward T. Linenthal Professor of History, Indiana University IUPUI’s Department of Religious Studies invites you to join one of the country’s foremost academic authorities on memorials and sacred spaces for a lecture on the development, building, and impact of the U.S. Holocaust Memorial Museum. April more »
          • IUPUI Department of Music and Arts Technology - Acoustic Guitar Ensemble
            April 24 7:30pm
            Acoustic Guitar Ensemble more »
          Monday, April 24, 2017