A free webinar on "Target Prioritization through Gene Expression Analysis" will be held from 10 to 11 a.m. Thursday, June 16.
The Indiana Clinical and Translational Sciences Institute's Access Technology Program provides investigators at Indiana University, Purdue University and the University of Notre Dame access to the Thomson Reuters pathway analysis software MetaCore and MetaDrug at a markedly reduced rate compared to purchase of a single user license.
Taking a systems biology approach using global gene expression data to compare diseased versus healthy biological samples can identify potential targets based on dysregulation profiles. However, statistical analysis of microarray data can result in a large number of significantly changed genes without any context to their biological roles and associated functions. This training session will use dataset GSE1297 to compare differentially expressed genes between Severe Alzheimer’s Disease and normal samples to address such questions as:
· How can we prioritize differentially expressed genes based on over-connectivity tests that eliminate literature bias?
· What known literature functional annotations can help reduce my list of potential targets?
· How do my prioritized targets from these DEGs fit into a pathway context?
There are no upcoming dates for this event.