• NCAA DI Men's Championships
    March 25 12:00am
    Swim Meet more »
  • CLOSED
    March 25 12:00am
    Closed more »
  • CLOSED
    March 26 12:00am
    The competition lap pool for lap swim is closed. more »
  • Competition Pool
    March 27 5:30am
    lap swim more »
  • 2017 IU Richard M. Fairbanks School of Public Health Department Breakfast and Event
    March 27 8:00am
    Marion County Health Department Event Alumni who work with the Marion County Health Department are welcome to join Fairbanks School of Public Health Founding Dean Paul Halverson, Dr. Virginia Caine, and members of the alumni association board of directors for an alumni networking breakfast. Enjoy a continental breakfast with colleagues wh more »
Saturday, March 25, 2017
    IU Calendar




    • NCAA DI Men's Championships
      March 25 12:00am
      Swim Meet more »
    • CLOSED
      March 25 12:00am
      Closed more »
    • CLOSED
      March 26 12:00am
      The competition lap pool for lap swim is closed. more »
    • Competition Pool
      March 27 5:30am
      lap swim more »
    • 2017 IU Richard M. Fairbanks School of Public Health Department Breakfast and Event
      March 27 8:00am
      Marion County Health Department Event Alumni who work with the Marion County Health Department are welcome to join Fairbanks School of Public Health Founding Dean Paul Halverson, Dr. Virginia Caine, and members of the alumni association board of directors for an alumni networking breakfast. Enjoy a continental breakfast with colleagues wh more »
    Saturday, March 25, 2017
      IU Calendar




      • NCAA DI Men's Championships
        March 25 12:00am
        Swim Meet more »
      • CLOSED
        March 25 12:00am
        Closed more »
      • CLOSED
        March 26 12:00am
        The competition lap pool for lap swim is closed. more »
      • Competition Pool
        March 27 5:30am
        lap swim more »
      • 2017 IU Richard M. Fairbanks School of Public Health Department Breakfast and Event
        March 27 8:00am
        Marion County Health Department Event Alumni who work with the Marion County Health Department are welcome to join Fairbanks School of Public Health Founding Dean Paul Halverson, Dr. Virginia Caine, and members of the alumni association board of directors for an alumni networking breakfast. Enjoy a continental breakfast with colleagues wh more »
      Saturday, March 25, 2017
        IU Calendar




        • NCAA DI Men's Championships
          March 25 12:00am
          Swim Meet more »
        • CLOSED
          March 25 12:00am
          Closed more »
        • CLOSED
          March 26 12:00am
          The competition lap pool for lap swim is closed. more »
        • Competition Pool
          March 27 5:30am
          lap swim more »
        • 2017 IU Richard M. Fairbanks School of Public Health Department Breakfast and Event
          March 27 8:00am
          Marion County Health Department Event Alumni who work with the Marion County Health Department are welcome to join Fairbanks School of Public Health Founding Dean Paul Halverson, Dr. Virginia Caine, and members of the alumni association board of directors for an alumni networking breakfast. Enjoy a continental breakfast with colleagues wh more »
        Saturday, March 25, 2017

          About This Event

          Summary

          Announcing the Final Examination of Huiying Zhao for the Degree of Doctor of Philosophy in informatics

          Dissertation: Protein function prediction by integrating sequence, structure and binding affinity information

          Proteins are nano-machines that work inside every living organism. Functional disruption of one or several proteins is the cause for many diseases. However, the functions for most proteins are yet to be annotated because inexpensive sequencing techniques dramatically speed up discovery of new protein sequences (265 million and counting) and experimental examinations of every protein in all its possible functional categories are simply impractical. Thus, it is necessary to develop computational function-prediction tools that complement and guide experimental studies. In this study, we developed a series of predictors for highly accurate prediction of proteins with DNA-binding, RNA-binding and carbohydrate-binding capability. These predictors are a template-based technique that combines sequence and structural information with predicted binding affinity. Both sequence and structure-based approaches were developed. Results indicate the importance of binding affinity prediction for improving sensitivity and precision of function prediction. Application of these methods to the human genome and structure genome targets demonstrated its usefulness in annotating proteins of unknown functions and discovering moon-lighting proteins with DNA, RNA, or carbohydrate binding function. The predictors are available at http://sparks.informatics.iupui.edu/spot.

          Education Career 

          • Major: Bioinformatics BS, North China University, 2001

          • Minor(s): Biostatistics 

          Committee in Charge

          • Yunlong Liu, PhD, Chairman, 317-278-9222

          • Yaoqi Zhou, PhD, Advisor

          • Samy Meroueh‎, PhD

          • Sarath Chandra Janga, PhD

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          Contact Information

          Mary O'Neill
          moneill@iupui.edu

          Event Site --- None ---
          Registration --- None ---

          Event Schedule

          There are no upcoming dates for this event.

          IU Calendar




          • NCAA DI Men's Championships
            March 25 12:00am
            Swim Meet more »
          • CLOSED
            March 25 12:00am
            Closed more »
          • CLOSED
            March 26 12:00am
            The competition lap pool for lap swim is closed. more »
          • Competition Pool
            March 27 5:30am
            lap swim more »
          • 2017 IU Richard M. Fairbanks School of Public Health Department Breakfast and Event
            March 27 8:00am
            Marion County Health Department Event Alumni who work with the Marion County Health Department are welcome to join Fairbanks School of Public Health Founding Dean Paul Halverson, Dr. Virginia Caine, and members of the alumni association board of directors for an alumni networking breakfast. Enjoy a continental breakfast with colleagues wh more »
          Saturday, March 25, 2017