• Competition Pool
    January 18 5:30am
    Lap Swim more »
  • Craig McDaniel + Jean Robertson | Close Reading
    January 18 10:00am
    In Close Reading, Herron faculty members Jean Robertson and Craig McDaniel explore the relationship of visual and verbal modes of communicating and expressing meaning. more »
  • Tom Sachs | Radiant City: Paintings 2000-2016
    January 18 10:00am
    A major survey exhibition of Tom Sachs’ paintings showcasing the artist’s ongoing interest in combining mass-produced pop cultural icons with a hand made aesthetic. This exhibition is made possible in part by the generous support of Julie and David Eskenazi. more »
  • Hans Op de Beeck | Staging Silence (2)
    January 18 10:00am
    In Belgian artist Hans Op de Beeck's film, the real and the imaginary fuse as anonymous hands assemble miniature dioramas of timeless, dreamlike settings. more »
  • Sophomore "Chew on This" Series
    January 18 12:00pm
    Calling all sophomores! This semester will be busy, so come by for tips and tricks to make this semester the best one. Free food and a change to win awesome JagSwag! more »
Wednesday, January 18, 2017
    IU Calendar




    • Competition Pool
      January 18 5:30am
      Lap Swim more »
    • Craig McDaniel + Jean Robertson | Close Reading
      January 18 10:00am
      In Close Reading, Herron faculty members Jean Robertson and Craig McDaniel explore the relationship of visual and verbal modes of communicating and expressing meaning. more »
    • Tom Sachs | Radiant City: Paintings 2000-2016
      January 18 10:00am
      A major survey exhibition of Tom Sachs’ paintings showcasing the artist’s ongoing interest in combining mass-produced pop cultural icons with a hand made aesthetic. This exhibition is made possible in part by the generous support of Julie and David Eskenazi. more »
    • Hans Op de Beeck | Staging Silence (2)
      January 18 10:00am
      In Belgian artist Hans Op de Beeck's film, the real and the imaginary fuse as anonymous hands assemble miniature dioramas of timeless, dreamlike settings. more »
    • Sophomore "Chew on This" Series
      January 18 12:00pm
      Calling all sophomores! This semester will be busy, so come by for tips and tricks to make this semester the best one. Free food and a change to win awesome JagSwag! more »
    Wednesday, January 18, 2017
      IU Calendar




      • Competition Pool
        January 18 5:30am
        Lap Swim more »
      • Craig McDaniel + Jean Robertson | Close Reading
        January 18 10:00am
        In Close Reading, Herron faculty members Jean Robertson and Craig McDaniel explore the relationship of visual and verbal modes of communicating and expressing meaning. more »
      • Tom Sachs | Radiant City: Paintings 2000-2016
        January 18 10:00am
        A major survey exhibition of Tom Sachs’ paintings showcasing the artist’s ongoing interest in combining mass-produced pop cultural icons with a hand made aesthetic. This exhibition is made possible in part by the generous support of Julie and David Eskenazi. more »
      • Hans Op de Beeck | Staging Silence (2)
        January 18 10:00am
        In Belgian artist Hans Op de Beeck's film, the real and the imaginary fuse as anonymous hands assemble miniature dioramas of timeless, dreamlike settings. more »
      • Sophomore "Chew on This" Series
        January 18 12:00pm
        Calling all sophomores! This semester will be busy, so come by for tips and tricks to make this semester the best one. Free food and a change to win awesome JagSwag! more »
      Wednesday, January 18, 2017
        IU Calendar




        • Competition Pool
          January 18 5:30am
          Lap Swim more »
        • Craig McDaniel + Jean Robertson | Close Reading
          January 18 10:00am
          In Close Reading, Herron faculty members Jean Robertson and Craig McDaniel explore the relationship of visual and verbal modes of communicating and expressing meaning. more »
        • Tom Sachs | Radiant City: Paintings 2000-2016
          January 18 10:00am
          A major survey exhibition of Tom Sachs’ paintings showcasing the artist’s ongoing interest in combining mass-produced pop cultural icons with a hand made aesthetic. This exhibition is made possible in part by the generous support of Julie and David Eskenazi. more »
        • Hans Op de Beeck | Staging Silence (2)
          January 18 10:00am
          In Belgian artist Hans Op de Beeck's film, the real and the imaginary fuse as anonymous hands assemble miniature dioramas of timeless, dreamlike settings. more »
        • Sophomore "Chew on This" Series
          January 18 12:00pm
          Calling all sophomores! This semester will be busy, so come by for tips and tricks to make this semester the best one. Free food and a change to win awesome JagSwag! more »
        Wednesday, January 18, 2017

          About This Event

          Summary

          Announcing the Final Examination of Huiying Zhao for the Degree of Doctor of Philosophy in informatics

          Dissertation: Protein function prediction by integrating sequence, structure and binding affinity information

          Proteins are nano-machines that work inside every living organism. Functional disruption of one or several proteins is the cause for many diseases. However, the functions for most proteins are yet to be annotated because inexpensive sequencing techniques dramatically speed up discovery of new protein sequences (265 million and counting) and experimental examinations of every protein in all its possible functional categories are simply impractical. Thus, it is necessary to develop computational function-prediction tools that complement and guide experimental studies. In this study, we developed a series of predictors for highly accurate prediction of proteins with DNA-binding, RNA-binding and carbohydrate-binding capability. These predictors are a template-based technique that combines sequence and structural information with predicted binding affinity. Both sequence and structure-based approaches were developed. Results indicate the importance of binding affinity prediction for improving sensitivity and precision of function prediction. Application of these methods to the human genome and structure genome targets demonstrated its usefulness in annotating proteins of unknown functions and discovering moon-lighting proteins with DNA, RNA, or carbohydrate binding function. The predictors are available at http://sparks.informatics.iupui.edu/spot.

          Education Career 

          • Major: Bioinformatics BS, North China University, 2001

          • Minor(s): Biostatistics 

          Committee in Charge

          • Yunlong Liu, PhD, Chairman, 317-278-9222

          • Yaoqi Zhou, PhD, Advisor

          • Samy Meroueh‎, PhD

          • Sarath Chandra Janga, PhD

          Bookmark and Share
          Contact Information

          Mary O'Neill
          moneill@iupui.edu

          Event Site --- None ---
          Registration --- None ---

          Event Schedule

          There are no upcoming dates for this event.

          IU Calendar




          • Competition Pool
            January 18 5:30am
            Lap Swim more »
          • Craig McDaniel + Jean Robertson | Close Reading
            January 18 10:00am
            In Close Reading, Herron faculty members Jean Robertson and Craig McDaniel explore the relationship of visual and verbal modes of communicating and expressing meaning. more »
          • Tom Sachs | Radiant City: Paintings 2000-2016
            January 18 10:00am
            A major survey exhibition of Tom Sachs’ paintings showcasing the artist’s ongoing interest in combining mass-produced pop cultural icons with a hand made aesthetic. This exhibition is made possible in part by the generous support of Julie and David Eskenazi. more »
          • Hans Op de Beeck | Staging Silence (2)
            January 18 10:00am
            In Belgian artist Hans Op de Beeck's film, the real and the imaginary fuse as anonymous hands assemble miniature dioramas of timeless, dreamlike settings. more »
          • Sophomore "Chew on This" Series
            January 18 12:00pm
            Calling all sophomores! This semester will be busy, so come by for tips and tricks to make this semester the best one. Free food and a change to win awesome JagSwag! more »
          Wednesday, January 18, 2017