• Competition Pool
    May 24 5:30am
    Lap swim more »
  • IU Pediatric Dental Alumni Suite
    May 25 12:00am
    For more information please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
  • Excel 2016: The Basics
    May 25 9:00am
    This session is being delivered online and simultaneously in room 144 in Wells Library in Bloomington. This is the online session, so please register for this session only if you plan to attend remotely. This workshop lasts 3 hours, a more »
  • IU Simon Cancer Center Summer Research Program Welcome Dinner
    May 25 4:00pm
    The IU Simon Cancer Center Summer Research Program aims to increase the number of undergraduate students from underrepresented populations pursuing biomedical and behavioral science careers by providing positive and meaningful firsthand exposure to these fields.   Tonight is the welcome dinner more »
  • Organizations and Religion; Religion, Spirituality, Healthcare, and Ethics Seminar
    May 25 6:00pm
    Facilitators:  Steven S. Ivy, PhD & David Craig, PhD Dinner and books will be provided free of charge. RSVP to srush7@iuhealth.org by May 11 so we can mail books and plan the meal. PLEASE PROVIDE A MAILING ADDRESS, CAMPUS OR US MAIL.   Readings:  Craig, D.M. (2014). Health care as a social good : religious more »
Wednesday, May 24, 2017
    IU Calendar




    • Competition Pool
      May 24 5:30am
      Lap swim more »
    • IU Pediatric Dental Alumni Suite
      May 25 12:00am
      For more information please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
    • Excel 2016: The Basics
      May 25 9:00am
      This session is being delivered online and simultaneously in room 144 in Wells Library in Bloomington. This is the online session, so please register for this session only if you plan to attend remotely. This workshop lasts 3 hours, a more »
    • IU Simon Cancer Center Summer Research Program Welcome Dinner
      May 25 4:00pm
      The IU Simon Cancer Center Summer Research Program aims to increase the number of undergraduate students from underrepresented populations pursuing biomedical and behavioral science careers by providing positive and meaningful firsthand exposure to these fields.   Tonight is the welcome dinner more »
    • Organizations and Religion; Religion, Spirituality, Healthcare, and Ethics Seminar
      May 25 6:00pm
      Facilitators:  Steven S. Ivy, PhD & David Craig, PhD Dinner and books will be provided free of charge. RSVP to srush7@iuhealth.org by May 11 so we can mail books and plan the meal. PLEASE PROVIDE A MAILING ADDRESS, CAMPUS OR US MAIL.   Readings:  Craig, D.M. (2014). Health care as a social good : religious more »
    Wednesday, May 24, 2017
      IU Calendar




      • Competition Pool
        May 24 5:30am
        Lap swim more »
      • IU Pediatric Dental Alumni Suite
        May 25 12:00am
        For more information please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
      • Excel 2016: The Basics
        May 25 9:00am
        This session is being delivered online and simultaneously in room 144 in Wells Library in Bloomington. This is the online session, so please register for this session only if you plan to attend remotely. This workshop lasts 3 hours, a more »
      • IU Simon Cancer Center Summer Research Program Welcome Dinner
        May 25 4:00pm
        The IU Simon Cancer Center Summer Research Program aims to increase the number of undergraduate students from underrepresented populations pursuing biomedical and behavioral science careers by providing positive and meaningful firsthand exposure to these fields.   Tonight is the welcome dinner more »
      • Organizations and Religion; Religion, Spirituality, Healthcare, and Ethics Seminar
        May 25 6:00pm
        Facilitators:  Steven S. Ivy, PhD & David Craig, PhD Dinner and books will be provided free of charge. RSVP to srush7@iuhealth.org by May 11 so we can mail books and plan the meal. PLEASE PROVIDE A MAILING ADDRESS, CAMPUS OR US MAIL.   Readings:  Craig, D.M. (2014). Health care as a social good : religious more »
      Wednesday, May 24, 2017
        IU Calendar




        • Competition Pool
          May 24 5:30am
          Lap swim more »
        • IU Pediatric Dental Alumni Suite
          May 25 12:00am
          For more information please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
        • Excel 2016: The Basics
          May 25 9:00am
          This session is being delivered online and simultaneously in room 144 in Wells Library in Bloomington. This is the online session, so please register for this session only if you plan to attend remotely. This workshop lasts 3 hours, a more »
        • IU Simon Cancer Center Summer Research Program Welcome Dinner
          May 25 4:00pm
          The IU Simon Cancer Center Summer Research Program aims to increase the number of undergraduate students from underrepresented populations pursuing biomedical and behavioral science careers by providing positive and meaningful firsthand exposure to these fields.   Tonight is the welcome dinner more »
        • Organizations and Religion; Religion, Spirituality, Healthcare, and Ethics Seminar
          May 25 6:00pm
          Facilitators:  Steven S. Ivy, PhD & David Craig, PhD Dinner and books will be provided free of charge. RSVP to srush7@iuhealth.org by May 11 so we can mail books and plan the meal. PLEASE PROVIDE A MAILING ADDRESS, CAMPUS OR US MAIL.   Readings:  Craig, D.M. (2014). Health care as a social good : religious more »
        Wednesday, May 24, 2017

          About This Event

          Summary

          Announcing the Final Examination of Huiying Zhao for the Degree of Doctor of Philosophy in informatics

          Dissertation: Protein function prediction by integrating sequence, structure and binding affinity information

          Proteins are nano-machines that work inside every living organism. Functional disruption of one or several proteins is the cause for many diseases. However, the functions for most proteins are yet to be annotated because inexpensive sequencing techniques dramatically speed up discovery of new protein sequences (265 million and counting) and experimental examinations of every protein in all its possible functional categories are simply impractical. Thus, it is necessary to develop computational function-prediction tools that complement and guide experimental studies. In this study, we developed a series of predictors for highly accurate prediction of proteins with DNA-binding, RNA-binding and carbohydrate-binding capability. These predictors are a template-based technique that combines sequence and structural information with predicted binding affinity. Both sequence and structure-based approaches were developed. Results indicate the importance of binding affinity prediction for improving sensitivity and precision of function prediction. Application of these methods to the human genome and structure genome targets demonstrated its usefulness in annotating proteins of unknown functions and discovering moon-lighting proteins with DNA, RNA, or carbohydrate binding function. The predictors are available at http://sparks.informatics.iupui.edu/spot.

          Education Career 

          • Major: Bioinformatics BS, North China University, 2001

          • Minor(s): Biostatistics 

          Committee in Charge

          • Yunlong Liu, PhD, Chairman, 317-278-9222

          • Yaoqi Zhou, PhD, Advisor

          • Samy Meroueh‎, PhD

          • Sarath Chandra Janga, PhD

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          Contact Information

          Mary O'Neill
          moneill@iupui.edu

          Event Site --- None ---
          Registration --- None ---

          Event Schedule

          There are no upcoming dates for this event.

          IU Calendar




          • Competition Pool
            May 24 5:30am
            Lap swim more »
          • IU Pediatric Dental Alumni Suite
            May 25 12:00am
            For more information please contact Karen Jones at kdeery@iupui.edu or 317-274-8959. more »
          • Excel 2016: The Basics
            May 25 9:00am
            This session is being delivered online and simultaneously in room 144 in Wells Library in Bloomington. This is the online session, so please register for this session only if you plan to attend remotely. This workshop lasts 3 hours, a more »
          • IU Simon Cancer Center Summer Research Program Welcome Dinner
            May 25 4:00pm
            The IU Simon Cancer Center Summer Research Program aims to increase the number of undergraduate students from underrepresented populations pursuing biomedical and behavioral science careers by providing positive and meaningful firsthand exposure to these fields.   Tonight is the welcome dinner more »
          • Organizations and Religion; Religion, Spirituality, Healthcare, and Ethics Seminar
            May 25 6:00pm
            Facilitators:  Steven S. Ivy, PhD & David Craig, PhD Dinner and books will be provided free of charge. RSVP to srush7@iuhealth.org by May 11 so we can mail books and plan the meal. PLEASE PROVIDE A MAILING ADDRESS, CAMPUS OR US MAIL.   Readings:  Craig, D.M. (2014). Health care as a social good : religious more »
          Wednesday, May 24, 2017