• Competition Pool
    December 15 11:00am
    Lap Swim more »
  • Mindfulness Meditation
    December 15 11:00am
    Feeling stressed and overwhelmed? Looking for an opportunity to practice self-care? Join us for guided mindfulness meditation. You don't have to be a CAPS client and no registration is needed. Student ID is required. more »
  • Marion County Swimming and Diving Championships
    December 15 4:00pm
    Swim meet hosted by Roncalli High School. more »
  • CLOSED
    December 16 12:00am
    Closed more »
  • Holiday Classic
    December 16 7:00am
    Columbus North Athletics sponsored swim meet. more »
Friday, December 15, 2017
    IU Calendar




    • Competition Pool
      December 15 11:00am
      Lap Swim more »
    • Mindfulness Meditation
      December 15 11:00am
      Feeling stressed and overwhelmed? Looking for an opportunity to practice self-care? Join us for guided mindfulness meditation. You don't have to be a CAPS client and no registration is needed. Student ID is required. more »
    • Marion County Swimming and Diving Championships
      December 15 4:00pm
      Swim meet hosted by Roncalli High School. more »
    • CLOSED
      December 16 12:00am
      Closed more »
    • Holiday Classic
      December 16 7:00am
      Columbus North Athletics sponsored swim meet. more »
    Friday, December 15, 2017
      IU Calendar




      • Competition Pool
        December 15 11:00am
        Lap Swim more »
      • Mindfulness Meditation
        December 15 11:00am
        Feeling stressed and overwhelmed? Looking for an opportunity to practice self-care? Join us for guided mindfulness meditation. You don't have to be a CAPS client and no registration is needed. Student ID is required. more »
      • Marion County Swimming and Diving Championships
        December 15 4:00pm
        Swim meet hosted by Roncalli High School. more »
      • CLOSED
        December 16 12:00am
        Closed more »
      • Holiday Classic
        December 16 7:00am
        Columbus North Athletics sponsored swim meet. more »
      Friday, December 15, 2017
        IU Calendar




        • Competition Pool
          December 15 11:00am
          Lap Swim more »
        • Mindfulness Meditation
          December 15 11:00am
          Feeling stressed and overwhelmed? Looking for an opportunity to practice self-care? Join us for guided mindfulness meditation. You don't have to be a CAPS client and no registration is needed. Student ID is required. more »
        • Marion County Swimming and Diving Championships
          December 15 4:00pm
          Swim meet hosted by Roncalli High School. more »
        • CLOSED
          December 16 12:00am
          Closed more »
        • Holiday Classic
          December 16 7:00am
          Columbus North Athletics sponsored swim meet. more »
        Friday, December 15, 2017

          About This Event

          Summary

          Announcing the Final Examination of Huiying Zhao for the Degree of Doctor of Philosophy in informatics

          Dissertation: Protein function prediction by integrating sequence, structure and binding affinity information

          Proteins are nano-machines that work inside every living organism. Functional disruption of one or several proteins is the cause for many diseases. However, the functions for most proteins are yet to be annotated because inexpensive sequencing techniques dramatically speed up discovery of new protein sequences (265 million and counting) and experimental examinations of every protein in all its possible functional categories are simply impractical. Thus, it is necessary to develop computational function-prediction tools that complement and guide experimental studies. In this study, we developed a series of predictors for highly accurate prediction of proteins with DNA-binding, RNA-binding and carbohydrate-binding capability. These predictors are a template-based technique that combines sequence and structural information with predicted binding affinity. Both sequence and structure-based approaches were developed. Results indicate the importance of binding affinity prediction for improving sensitivity and precision of function prediction. Application of these methods to the human genome and structure genome targets demonstrated its usefulness in annotating proteins of unknown functions and discovering moon-lighting proteins with DNA, RNA, or carbohydrate binding function. The predictors are available at http://sparks.informatics.iupui.edu/spot.

          Education Career 

          • Major: Bioinformatics BS, North China University, 2001

          • Minor(s): Biostatistics 

          Committee in Charge

          • Yunlong Liu, PhD, Chairman, 317-278-9222

          • Yaoqi Zhou, PhD, Advisor

          • Samy Meroueh‎, PhD

          • Sarath Chandra Janga, PhD

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          Contact Information

          Mary O'Neill
          moneill@iupui.edu

          Event Site --- None ---
          Registration --- None ---

          Event Schedule

          There are no upcoming dates for this event.

          IU Calendar




          • Competition Pool
            December 15 11:00am
            Lap Swim more »
          • Mindfulness Meditation
            December 15 11:00am
            Feeling stressed and overwhelmed? Looking for an opportunity to practice self-care? Join us for guided mindfulness meditation. You don't have to be a CAPS client and no registration is needed. Student ID is required. more »
          • Marion County Swimming and Diving Championships
            December 15 4:00pm
            Swim meet hosted by Roncalli High School. more »
          • CLOSED
            December 16 12:00am
            Closed more »
          • Holiday Classic
            December 16 7:00am
            Columbus North Athletics sponsored swim meet. more »
          Friday, December 15, 2017