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Saturday, August 19, 2017
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    • CLOSED
      August 19 12:00am
      Closed more »
    • WOW: First Night
      August 19 7:00pm
      Start the year off right in the Campus Center with an evening full of fun activities and free snacks.  more »
    • CLOSED
      August 20 12:00am
      The competition lap pool for lap swim is closed. more »
    • FINA Jr. World Championships
      August 20 12:00am
      swim meet more »
    • All Resident Meeting
      August 20 4:00pm
      All students who live on campus will be invited to attend the All Resident Meeting in Carroll Stadium.  Students will have an opportunity to learn about involvement with Housing and Residence Life, understand Housing and Residence Life policies and how to get the most from living on campus. If incliment weather or unsafe conditions exis more »
    Saturday, August 19, 2017
      IU Calendar




      • CLOSED
        August 19 12:00am
        Closed more »
      • WOW: First Night
        August 19 7:00pm
        Start the year off right in the Campus Center with an evening full of fun activities and free snacks.  more »
      • CLOSED
        August 20 12:00am
        The competition lap pool for lap swim is closed. more »
      • FINA Jr. World Championships
        August 20 12:00am
        swim meet more »
      • All Resident Meeting
        August 20 4:00pm
        All students who live on campus will be invited to attend the All Resident Meeting in Carroll Stadium.  Students will have an opportunity to learn about involvement with Housing and Residence Life, understand Housing and Residence Life policies and how to get the most from living on campus. If incliment weather or unsafe conditions exis more »
      Saturday, August 19, 2017
        IU Calendar




        • CLOSED
          August 19 12:00am
          Closed more »
        • WOW: First Night
          August 19 7:00pm
          Start the year off right in the Campus Center with an evening full of fun activities and free snacks.  more »
        • CLOSED
          August 20 12:00am
          The competition lap pool for lap swim is closed. more »
        • FINA Jr. World Championships
          August 20 12:00am
          swim meet more »
        • All Resident Meeting
          August 20 4:00pm
          All students who live on campus will be invited to attend the All Resident Meeting in Carroll Stadium.  Students will have an opportunity to learn about involvement with Housing and Residence Life, understand Housing and Residence Life policies and how to get the most from living on campus. If incliment weather or unsafe conditions exis more »
        Saturday, August 19, 2017

          About This Event

          Summary

          The Department of Chemistry and Chemical Biology in the School of Science at IUPUI will host the inaugural Westheimer Lecture Series the week of April 22.

          April 22 @1pm | Lilly Auditorium in the University Library

          The Contributions of Frank Westheimer to Biological Organic Chemistry

          Presented by Dr. G. Michael Blackburn of the University of Sheffield

          Dr. G. Michael Blackburn of the University of Sheffield will present the first lecture at 1 p.m. on April 22 in the Lilly Auditorium, lower level of the University Library. Titled "The Contributions of Frank Westheimer to Biological Organic Chemistry," the lecture will discuss the impact of American chemist Dr. Westheimer, former Harvard University professor. Westheimer, who passed away in 2007, is one of the earliest researchers in the area of physical organic chemistry. Among his honors were the Priestley Medal in 1988, the U.S. National Medal of Science, the U.S. National Academy Award in Chemical Sciences and the Robert A. Welch Foundation Award.

          The presentation will explore Westheimer’s early work in Harvard on enzyme mechanisms, his quantitative analysis of the reactions of phosphate esters and mechanistic proposals thereby derived, and his engagement with the centrality of phosphorus in life, employing a blend of objective and subjective views. That will lead into a contemporary survey of the possibility of alternatives to phosphate and a critical view of arsenate as a surrogate for phosphate. It will expose the central paradox of phosphate esters in life as the necessary characteristic of their truly universal deployment. Lastly, the presentation will survey the range of experimental and computational methods that have been deployed to bring studies on enzyme mechanisms of phosphoryl group transfer to their present advanced state and some of Sheffield University contributions to that knowledge. 

          Frank H. Westheimer (1912 - 2007) was Morris Loeb Professor of Chemistry Emeritus at Harvard University. After earning his Ph.D. from Harvard, he trained in Columbia with Louis P Hammett, the father of physical organic chemistry, and also studied physics and electrostatics plus statistical mechanics. Those skills equipped him in Chicago to study isotopes and their uses in organic chemistry and led him into a study of enzyme mechanisms.

          A renewed interest in organophosphorus compounds and their reaction mechanisms led into problems related to phosphate processes in biochemistry, especially for adenosine triphosphate and ribonuclease. These called for new experimental techniques and their analysis demanded dramatically new concepts in reactivity, especially related to dynamic stereochemistry.

          As an Emeritus Harvard Professor, he became committed to understanding the fundamental role of phosphorus in life and attempted to rationalize it in terms of the breadth of his knowledge of phosphates.  Frank Westheimer is regarded as the Father of Mechanistic Biological Chemistry by many of his successors and followers.

          April 25 @5pm | IT, Room 90

          Strain Catalysis: Westheimer and Beyond

          Blackburn will continue the series at 5 p.m. on April 25 in IT Room 90 with "Strain Catalysis: Westheimer and Beyond."

          Westheimer was deeply committed to the concept of strain in the reactions of phosphate di- and tri-esters in relation to ribonuclease. This presentation will briefly outline his work on enzyme mechanisms and relate that to present-day studies to show the strength and limits of his work. From there, the presentation will involve a discussion of current opinions on the role of strain in enzyme catalysis and bring that to focus on work in Sheffield on a unique DNA repair enzyme, Uracil DNA Glycohydrolase, which many believe to be a prominent example of Strain Catalysis.

          April 26 @1pm | Lecture Hall 105

          Resolving Enzyme Mechanisms of Phosphate Transfer

          The final lecture, "Resolving Enzyme Mechanisms of Phosphate Transfer," will be at 1 p.m. on April 26 in Lecture Hall 105.

          Enzyme catalyzed phosphoryl transfer mechanisms lie at the heart of life. This presentation will illustrate this using the biosynthesis of ATP involving a proton gradient across a membrane, by the polymerisation of RNA using ATP etc., and by energy production from metabolising glucose via 1,3-diphosphoglyceric acid. The strengths and also the shortcomings of analysis of protein structures by crystallography divorced from chemistry will be exemplified. Finally the centrality of studies on transition states to understand mechanisms will be applied to a unified theory of phosphoryl transfer in the isomerisation, hydrolysis, and alcoholysis of phosphate monoesters and anhydrides.

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          IU Calendar




          • CLOSED
            August 19 12:00am
            Closed more »
          • WOW: First Night
            August 19 7:00pm
            Start the year off right in the Campus Center with an evening full of fun activities and free snacks.  more »
          • CLOSED
            August 20 12:00am
            The competition lap pool for lap swim is closed. more »
          • FINA Jr. World Championships
            August 20 12:00am
            swim meet more »
          • All Resident Meeting
            August 20 4:00pm
            All students who live on campus will be invited to attend the All Resident Meeting in Carroll Stadium.  Students will have an opportunity to learn about involvement with Housing and Residence Life, understand Housing and Residence Life policies and how to get the most from living on campus. If incliment weather or unsafe conditions exis more »
          Saturday, August 19, 2017