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    December 05 5:30am
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  • CyberSec First Responder: Threat Detection and Response
    December 05 9:00am
    This workshop lasts 5 days. Overview: This course covers the duties of those who are responsible for monitoring and detecting security incidents in information systems and networks, and for executing a proper response to such incidents. Depending on the size of the organization, this individual more »
  • Al-Mutanabbi Street Starts Here
    December 05 10:00am
    A car bomb exploded in 2007 in the historic intellectual center of Baghdad, al-Mutanabbi Street. More than 130 people died or were wounded, but the place escaped geographic bounds to become a global movement for the free exchange of ideas. View selections from a rare collection of artist's books and broadsides that continue to be generated a more »
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    December 05 10:00am
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    December 05 5:00pm
    Lap swim is available in the competition pool more »
Monday, December 5, 2016
    IU Calendar




    • Competition Pool
      December 05 5:30am
      Lap swim in the competition pool more »
    • CyberSec First Responder: Threat Detection and Response
      December 05 9:00am
      This workshop lasts 5 days. Overview: This course covers the duties of those who are responsible for monitoring and detecting security incidents in information systems and networks, and for executing a proper response to such incidents. Depending on the size of the organization, this individual more »
    • Al-Mutanabbi Street Starts Here
      December 05 10:00am
      A car bomb exploded in 2007 in the historic intellectual center of Baghdad, al-Mutanabbi Street. More than 130 people died or were wounded, but the place escaped geographic bounds to become a global movement for the free exchange of ideas. View selections from a rare collection of artist's books and broadsides that continue to be generated a more »
    • Undergraduate Student Exhibition
      December 05 10:00am
      The Undergraduate Student Exhibition is juried by Liz Garvey of Simon Garvey Art Access Gallery in New York. Works are typically selected from hundreds of submission across a wide variety of media. more »
    • Competition Pool
      December 05 5:00pm
      Lap swim is available in the competition pool more »
    Monday, December 5, 2016
      IU Calendar




      • Competition Pool
        December 05 5:30am
        Lap swim in the competition pool more »
      • CyberSec First Responder: Threat Detection and Response
        December 05 9:00am
        This workshop lasts 5 days. Overview: This course covers the duties of those who are responsible for monitoring and detecting security incidents in information systems and networks, and for executing a proper response to such incidents. Depending on the size of the organization, this individual more »
      • Al-Mutanabbi Street Starts Here
        December 05 10:00am
        A car bomb exploded in 2007 in the historic intellectual center of Baghdad, al-Mutanabbi Street. More than 130 people died or were wounded, but the place escaped geographic bounds to become a global movement for the free exchange of ideas. View selections from a rare collection of artist's books and broadsides that continue to be generated a more »
      • Undergraduate Student Exhibition
        December 05 10:00am
        The Undergraduate Student Exhibition is juried by Liz Garvey of Simon Garvey Art Access Gallery in New York. Works are typically selected from hundreds of submission across a wide variety of media. more »
      • Competition Pool
        December 05 5:00pm
        Lap swim is available in the competition pool more »
      Monday, December 5, 2016
        IU Calendar




        • Competition Pool
          December 05 5:30am
          Lap swim in the competition pool more »
        • CyberSec First Responder: Threat Detection and Response
          December 05 9:00am
          This workshop lasts 5 days. Overview: This course covers the duties of those who are responsible for monitoring and detecting security incidents in information systems and networks, and for executing a proper response to such incidents. Depending on the size of the organization, this individual more »
        • Al-Mutanabbi Street Starts Here
          December 05 10:00am
          A car bomb exploded in 2007 in the historic intellectual center of Baghdad, al-Mutanabbi Street. More than 130 people died or were wounded, but the place escaped geographic bounds to become a global movement for the free exchange of ideas. View selections from a rare collection of artist's books and broadsides that continue to be generated a more »
        • Undergraduate Student Exhibition
          December 05 10:00am
          The Undergraduate Student Exhibition is juried by Liz Garvey of Simon Garvey Art Access Gallery in New York. Works are typically selected from hundreds of submission across a wide variety of media. more »
        • Competition Pool
          December 05 5:00pm
          Lap swim is available in the competition pool more »
        Monday, December 5, 2016

          About This Event

          Summary

          The Department of Chemistry and Chemical Biology in the School of Science at IUPUI will host the inaugural Westheimer Lecture Series the week of April 22.

          April 22 @1pm | Lilly Auditorium in the University Library

          The Contributions of Frank Westheimer to Biological Organic Chemistry

          Presented by Dr. G. Michael Blackburn of the University of Sheffield

          Dr. G. Michael Blackburn of the University of Sheffield will present the first lecture at 1 p.m. on April 22 in the Lilly Auditorium, lower level of the University Library. Titled "The Contributions of Frank Westheimer to Biological Organic Chemistry," the lecture will discuss the impact of American chemist Dr. Westheimer, former Harvard University professor. Westheimer, who passed away in 2007, is one of the earliest researchers in the area of physical organic chemistry. Among his honors were the Priestley Medal in 1988, the U.S. National Medal of Science, the U.S. National Academy Award in Chemical Sciences and the Robert A. Welch Foundation Award.

          The presentation will explore Westheimer’s early work in Harvard on enzyme mechanisms, his quantitative analysis of the reactions of phosphate esters and mechanistic proposals thereby derived, and his engagement with the centrality of phosphorus in life, employing a blend of objective and subjective views. That will lead into a contemporary survey of the possibility of alternatives to phosphate and a critical view of arsenate as a surrogate for phosphate. It will expose the central paradox of phosphate esters in life as the necessary characteristic of their truly universal deployment. Lastly, the presentation will survey the range of experimental and computational methods that have been deployed to bring studies on enzyme mechanisms of phosphoryl group transfer to their present advanced state and some of Sheffield University contributions to that knowledge. 

          Frank H. Westheimer (1912 - 2007) was Morris Loeb Professor of Chemistry Emeritus at Harvard University. After earning his Ph.D. from Harvard, he trained in Columbia with Louis P Hammett, the father of physical organic chemistry, and also studied physics and electrostatics plus statistical mechanics. Those skills equipped him in Chicago to study isotopes and their uses in organic chemistry and led him into a study of enzyme mechanisms.

          A renewed interest in organophosphorus compounds and their reaction mechanisms led into problems related to phosphate processes in biochemistry, especially for adenosine triphosphate and ribonuclease. These called for new experimental techniques and their analysis demanded dramatically new concepts in reactivity, especially related to dynamic stereochemistry.

          As an Emeritus Harvard Professor, he became committed to understanding the fundamental role of phosphorus in life and attempted to rationalize it in terms of the breadth of his knowledge of phosphates.  Frank Westheimer is regarded as the Father of Mechanistic Biological Chemistry by many of his successors and followers.

          April 25 @5pm | IT, Room 90

          Strain Catalysis: Westheimer and Beyond

          Blackburn will continue the series at 5 p.m. on April 25 in IT Room 90 with "Strain Catalysis: Westheimer and Beyond."

          Westheimer was deeply committed to the concept of strain in the reactions of phosphate di- and tri-esters in relation to ribonuclease. This presentation will briefly outline his work on enzyme mechanisms and relate that to present-day studies to show the strength and limits of his work. From there, the presentation will involve a discussion of current opinions on the role of strain in enzyme catalysis and bring that to focus on work in Sheffield on a unique DNA repair enzyme, Uracil DNA Glycohydrolase, which many believe to be a prominent example of Strain Catalysis.

          April 26 @1pm | Lecture Hall 105

          Resolving Enzyme Mechanisms of Phosphate Transfer

          The final lecture, "Resolving Enzyme Mechanisms of Phosphate Transfer," will be at 1 p.m. on April 26 in Lecture Hall 105.

          Enzyme catalyzed phosphoryl transfer mechanisms lie at the heart of life. This presentation will illustrate this using the biosynthesis of ATP involving a proton gradient across a membrane, by the polymerisation of RNA using ATP etc., and by energy production from metabolising glucose via 1,3-diphosphoglyceric acid. The strengths and also the shortcomings of analysis of protein structures by crystallography divorced from chemistry will be exemplified. Finally the centrality of studies on transition states to understand mechanisms will be applied to a unified theory of phosphoryl transfer in the isomerisation, hydrolysis, and alcoholysis of phosphate monoesters and anhydrides.

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          IU Calendar




          • Competition Pool
            December 05 5:30am
            Lap swim in the competition pool more »
          • CyberSec First Responder: Threat Detection and Response
            December 05 9:00am
            This workshop lasts 5 days. Overview: This course covers the duties of those who are responsible for monitoring and detecting security incidents in information systems and networks, and for executing a proper response to such incidents. Depending on the size of the organization, this individual more »
          • Al-Mutanabbi Street Starts Here
            December 05 10:00am
            A car bomb exploded in 2007 in the historic intellectual center of Baghdad, al-Mutanabbi Street. More than 130 people died or were wounded, but the place escaped geographic bounds to become a global movement for the free exchange of ideas. View selections from a rare collection of artist's books and broadsides that continue to be generated a more »
          • Undergraduate Student Exhibition
            December 05 10:00am
            The Undergraduate Student Exhibition is juried by Liz Garvey of Simon Garvey Art Access Gallery in New York. Works are typically selected from hundreds of submission across a wide variety of media. more »
          • Competition Pool
            December 05 5:00pm
            Lap swim is available in the competition pool more »
          Monday, December 5, 2016