• Field Day
    August 27 4:00pm
    Form a team for some friendly competition and join us for field day classics and fun! more »
  • Alumni Night at Symphony on the Prairie Concert with a Cause
    August 27 6:00pm
    WHO'S BAD: MUSIC OF MICHAEL JACKSON Saturday, August 27       Thrilling fans for more than a decade, the Ultimate Michael Jackson Tribute Band brings the chart-topping music and jaw-dropping dance moves of the undisputed King of Pop to Conner Prairie. Sing and dance along to your favorite Michael Jackson hits more »
  • SAPB Late Night & Weekends: Laser Tag
    August 27 8:00pm
    This event provides an opportunity for students to connect with each other on campus. It also provides an opportunity for students to have fun and relax after the first week of school. This event will have a laser tag arena, food, and other games.  more »
  • IUPUI Discovers Indy
    August 28 2:00pm
    Register for this great event to spend the day explore new places in Indianapolis and learn what this great city has to offer. more »
  • Student Support Centers Resource Fair
    August 29 8:00am
    The Student Support Centers Resource Fair will include academic support services from around the IUPUI campus.  Groups will share program information, discuss valuable material from their area, and answer any questions.  Students will gain an increased awareness of academic resources on campus that can assist them in their academic suc more »
Saturday, August 27, 2016
    IU Calendar




    • Field Day
      August 27 4:00pm
      Form a team for some friendly competition and join us for field day classics and fun! more »
    • Alumni Night at Symphony on the Prairie Concert with a Cause
      August 27 6:00pm
      WHO'S BAD: MUSIC OF MICHAEL JACKSON Saturday, August 27       Thrilling fans for more than a decade, the Ultimate Michael Jackson Tribute Band brings the chart-topping music and jaw-dropping dance moves of the undisputed King of Pop to Conner Prairie. Sing and dance along to your favorite Michael Jackson hits more »
    • SAPB Late Night & Weekends: Laser Tag
      August 27 8:00pm
      This event provides an opportunity for students to connect with each other on campus. It also provides an opportunity for students to have fun and relax after the first week of school. This event will have a laser tag arena, food, and other games.  more »
    • IUPUI Discovers Indy
      August 28 2:00pm
      Register for this great event to spend the day explore new places in Indianapolis and learn what this great city has to offer. more »
    • Student Support Centers Resource Fair
      August 29 8:00am
      The Student Support Centers Resource Fair will include academic support services from around the IUPUI campus.  Groups will share program information, discuss valuable material from their area, and answer any questions.  Students will gain an increased awareness of academic resources on campus that can assist them in their academic suc more »
    Saturday, August 27, 2016
      IU Calendar




      • Field Day
        August 27 4:00pm
        Form a team for some friendly competition and join us for field day classics and fun! more »
      • Alumni Night at Symphony on the Prairie Concert with a Cause
        August 27 6:00pm
        WHO'S BAD: MUSIC OF MICHAEL JACKSON Saturday, August 27       Thrilling fans for more than a decade, the Ultimate Michael Jackson Tribute Band brings the chart-topping music and jaw-dropping dance moves of the undisputed King of Pop to Conner Prairie. Sing and dance along to your favorite Michael Jackson hits more »
      • SAPB Late Night & Weekends: Laser Tag
        August 27 8:00pm
        This event provides an opportunity for students to connect with each other on campus. It also provides an opportunity for students to have fun and relax after the first week of school. This event will have a laser tag arena, food, and other games.  more »
      • IUPUI Discovers Indy
        August 28 2:00pm
        Register for this great event to spend the day explore new places in Indianapolis and learn what this great city has to offer. more »
      • Student Support Centers Resource Fair
        August 29 8:00am
        The Student Support Centers Resource Fair will include academic support services from around the IUPUI campus.  Groups will share program information, discuss valuable material from their area, and answer any questions.  Students will gain an increased awareness of academic resources on campus that can assist them in their academic suc more »
      Saturday, August 27, 2016
        IU Calendar




        • Field Day
          August 27 4:00pm
          Form a team for some friendly competition and join us for field day classics and fun! more »
        • Alumni Night at Symphony on the Prairie Concert with a Cause
          August 27 6:00pm
          WHO'S BAD: MUSIC OF MICHAEL JACKSON Saturday, August 27       Thrilling fans for more than a decade, the Ultimate Michael Jackson Tribute Band brings the chart-topping music and jaw-dropping dance moves of the undisputed King of Pop to Conner Prairie. Sing and dance along to your favorite Michael Jackson hits more »
        • SAPB Late Night & Weekends: Laser Tag
          August 27 8:00pm
          This event provides an opportunity for students to connect with each other on campus. It also provides an opportunity for students to have fun and relax after the first week of school. This event will have a laser tag arena, food, and other games.  more »
        • IUPUI Discovers Indy
          August 28 2:00pm
          Register for this great event to spend the day explore new places in Indianapolis and learn what this great city has to offer. more »
        • Student Support Centers Resource Fair
          August 29 8:00am
          The Student Support Centers Resource Fair will include academic support services from around the IUPUI campus.  Groups will share program information, discuss valuable material from their area, and answer any questions.  Students will gain an increased awareness of academic resources on campus that can assist them in their academic suc more »
        Saturday, August 27, 2016

          About This Event

          Summary

          The Department of Chemistry and Chemical Biology in the School of Science at IUPUI will host the inaugural Westheimer Lecture Series the week of April 22.

          April 22 @1pm | Lilly Auditorium in the University Library

          The Contributions of Frank Westheimer to Biological Organic Chemistry

          Presented by Dr. G. Michael Blackburn of the University of Sheffield

          Dr. G. Michael Blackburn of the University of Sheffield will present the first lecture at 1 p.m. on April 22 in the Lilly Auditorium, lower level of the University Library. Titled "The Contributions of Frank Westheimer to Biological Organic Chemistry," the lecture will discuss the impact of American chemist Dr. Westheimer, former Harvard University professor. Westheimer, who passed away in 2007, is one of the earliest researchers in the area of physical organic chemistry. Among his honors were the Priestley Medal in 1988, the U.S. National Medal of Science, the U.S. National Academy Award in Chemical Sciences and the Robert A. Welch Foundation Award.

          The presentation will explore Westheimer’s early work in Harvard on enzyme mechanisms, his quantitative analysis of the reactions of phosphate esters and mechanistic proposals thereby derived, and his engagement with the centrality of phosphorus in life, employing a blend of objective and subjective views. That will lead into a contemporary survey of the possibility of alternatives to phosphate and a critical view of arsenate as a surrogate for phosphate. It will expose the central paradox of phosphate esters in life as the necessary characteristic of their truly universal deployment. Lastly, the presentation will survey the range of experimental and computational methods that have been deployed to bring studies on enzyme mechanisms of phosphoryl group transfer to their present advanced state and some of Sheffield University contributions to that knowledge. 

          Frank H. Westheimer (1912 - 2007) was Morris Loeb Professor of Chemistry Emeritus at Harvard University. After earning his Ph.D. from Harvard, he trained in Columbia with Louis P Hammett, the father of physical organic chemistry, and also studied physics and electrostatics plus statistical mechanics. Those skills equipped him in Chicago to study isotopes and their uses in organic chemistry and led him into a study of enzyme mechanisms.

          A renewed interest in organophosphorus compounds and their reaction mechanisms led into problems related to phosphate processes in biochemistry, especially for adenosine triphosphate and ribonuclease. These called for new experimental techniques and their analysis demanded dramatically new concepts in reactivity, especially related to dynamic stereochemistry.

          As an Emeritus Harvard Professor, he became committed to understanding the fundamental role of phosphorus in life and attempted to rationalize it in terms of the breadth of his knowledge of phosphates.  Frank Westheimer is regarded as the Father of Mechanistic Biological Chemistry by many of his successors and followers.

          April 25 @5pm | IT, Room 90

          Strain Catalysis: Westheimer and Beyond

          Blackburn will continue the series at 5 p.m. on April 25 in IT Room 90 with "Strain Catalysis: Westheimer and Beyond."

          Westheimer was deeply committed to the concept of strain in the reactions of phosphate di- and tri-esters in relation to ribonuclease. This presentation will briefly outline his work on enzyme mechanisms and relate that to present-day studies to show the strength and limits of his work. From there, the presentation will involve a discussion of current opinions on the role of strain in enzyme catalysis and bring that to focus on work in Sheffield on a unique DNA repair enzyme, Uracil DNA Glycohydrolase, which many believe to be a prominent example of Strain Catalysis.

          April 26 @1pm | Lecture Hall 105

          Resolving Enzyme Mechanisms of Phosphate Transfer

          The final lecture, "Resolving Enzyme Mechanisms of Phosphate Transfer," will be at 1 p.m. on April 26 in Lecture Hall 105.

          Enzyme catalyzed phosphoryl transfer mechanisms lie at the heart of life. This presentation will illustrate this using the biosynthesis of ATP involving a proton gradient across a membrane, by the polymerisation of RNA using ATP etc., and by energy production from metabolising glucose via 1,3-diphosphoglyceric acid. The strengths and also the shortcomings of analysis of protein structures by crystallography divorced from chemistry will be exemplified. Finally the centrality of studies on transition states to understand mechanisms will be applied to a unified theory of phosphoryl transfer in the isomerisation, hydrolysis, and alcoholysis of phosphate monoesters and anhydrides.

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          Event Schedule

          There are no upcoming dates for this event.

          IU Calendar




          • Field Day
            August 27 4:00pm
            Form a team for some friendly competition and join us for field day classics and fun! more »
          • Alumni Night at Symphony on the Prairie Concert with a Cause
            August 27 6:00pm
            WHO'S BAD: MUSIC OF MICHAEL JACKSON Saturday, August 27       Thrilling fans for more than a decade, the Ultimate Michael Jackson Tribute Band brings the chart-topping music and jaw-dropping dance moves of the undisputed King of Pop to Conner Prairie. Sing and dance along to your favorite Michael Jackson hits more »
          • SAPB Late Night & Weekends: Laser Tag
            August 27 8:00pm
            This event provides an opportunity for students to connect with each other on campus. It also provides an opportunity for students to have fun and relax after the first week of school. This event will have a laser tag arena, food, and other games.  more »
          • IUPUI Discovers Indy
            August 28 2:00pm
            Register for this great event to spend the day explore new places in Indianapolis and learn what this great city has to offer. more »
          • Student Support Centers Resource Fair
            August 29 8:00am
            The Student Support Centers Resource Fair will include academic support services from around the IUPUI campus.  Groups will share program information, discuss valuable material from their area, and answer any questions.  Students will gain an increased awareness of academic resources on campus that can assist them in their academic suc more »
          Saturday, August 27, 2016